学习经历

2006年9月-2010年7月  华中师范大学 学士

2010年9月-2012年7月  中国科学院武汉物理与数学研究所 硕转博

2012年9月-2015年7月  中国科学院武汉物理与数学研究所 博士

工作经历

2015年9月-2019年10月  中国科学院武汉物理与数学研究所 助理研究员

2016年2月-2019年4月  美国宾夕法尼亚州立大学医学院 博士后

2019年5月-2024年5月  美国宾夕法尼亚州立大学医学院 Research Associate

2024年6月-今  中国科学院精密测量科学与技术创新研究院 副研究员

（1）原位生物大分子波谱分析

（2）界面蛋白功能磁共振分析

（3）自噬相关分子的工作机制

[1] Yansheng Ye #, Erin R Tyndall #, Van Bui #, Maria C. Bewley, Guifang Wang, Xupeng Hong, Yang Shen, John M. Flanagan, Hong-Gang Wang*, Fang Tian*. Multifaceted Membrane Interactions of Human Atg3 Promote LC3-Phosphatidylethanolamine Conjugation during Autophagy. Nat. Commun. 2023, 14(1):5503.

[2] Yansheng Ye #, Erin R Tyndall #, Van Bui #, Zhenyuan Tang, Yang Shen, Xuejun Jiang, John M Flanagan, Hong-Gang Wang*, Fang Tian*. An N-terminal conserved region in human Atg3 couples membrane curvature sensitivity to conjugase activity during autophagy, Nat. Commun. 2021, 12(1):374.

[3] Yansheng Ye, Xiaoli Liu, Guohua Xu, Maili Liu and Conggang Li*. Direct Observation of Ca2+-induced Conformational Transition of Calmodulin in Intact Xenopus laevis Oocytes by 19F NMR, Angew. Chem. Int. Ed. 2015, 54, 5328-5330.

[4] Yansheng Ye*#, Xinwen Liang #, Guifang Wang, Maria C Bewley, Kouta Hamamoto, Xiaoming Liu, John M. Flanagan, Hong-Gang Wang, Yoshinori Takahashi*, Fang Tian*. Identification of Membrane Curvature Sensing Motifs Essential for VPS37A Phagophore Recruitment and Autophagosome Closure. Commun Biol. 2024,7(1):334.

[5] Yansheng Ye, Maria C Bewley, Hong-Gang Wang, Fang Tian*, John M Flanagan*. What's in an E3: role of highly curved membranes in facilitating LC3-phosphatidylethanolamine conjugation during autophagy. Autophagy. 2024,20(3):709-711.

[6] Jennifer M Atkinson #, Yansheng Ye #, Melat T Gebru, Qiang Liu, Shouhao Zhou, Megan M Young, Yoshinori Takahashi, Qing Lin, Fang Tian*, Hong-Gang Wang*. Time-resolved FRET and NMR Analyses Reveal Selective Binding of Peptides Containing the LC3-interacting Region to ATG8 Family Proteins, J. Biol. Chem. 2019, 294(38):14033-14042.

[7] Yansheng Ye #, Qiong Wu #, Wenwen Zheng, Bin Jiang, Gary J Pielak, Maili Liu, Conggang Li*. Positively Charged Tags Impede Protein Mobility in Cells as Quantified by 19F NMR, J. Phys. Chem. B. 2019, 123(21):4527-4533.

[8] Yansheng Ye #, Qiong Wu #, Wenwen Zheng, Bin Jiang, Gary J Pielak , Maili Liu, Conggang Li*. Quantification of size effect on protein rotational mobility in cells by 19F NMR spectroscopy, Anal. Bioanal. Chem. 2018, 410(3):869-874.

[9] Yansheng Ye, Xiaoli Liu, Yanhua Chen, Guohua Xu, Qiong Wu, Zeting Zhang, Chendie Yao, Maili Liu, Conggang Li*. Labeling Strategy and Signal Broadening Mechanism of Protein NMR in Xenopus laevis Oocytes, Chem. Eur. J. 2015, 21, 8686-8690.

[10] Yansheng Ye, Xiaoli Liu, Zeting Zhang, Qiong Wu, Bin Jiang, Ling Jiang, Xu Zhang, Maili Liu*, Gary J Pielak*, Conggang Li*. 19F NMR Spectroscopy as a Probe of Cytoplasmic Viscosity and Weak Protein Interactions in Living Cells, Chem. Eur. J. 2013, 19, 12705-10.